Drilling during Leg 119 (1988) and Leg 188 (2000; Sites 1165-1167) of the Ocean Drilling Program (ODP) provides direct evidence for long- and short-term changes in Cenozoic paleoenvironments in the Prydz Bay region. Cores from across the continental margin reveal that in preglacial times the present shelf was an alluvial plain system with austral conifer woodland in the Late Cretaceous that changed to cooler Nothofagus rainforest scrub by the middle to late Eocene (Site 1166). Earliest recovered evidence of nearby mountain glaciation is seen in late Eocene-age grain textures in fluvial sands. In the late Eocene to early Oligocene, Prydz Bay permanently shifted from being a fluvio-deltaic complex to an exclusively marine continental shelf environment. This transition is marked by a marine flooding surface later covered by overcompacted glacial sediments that denote the first advance of the ice sheet onto the shelf. Cores do not exist for the early Oligocene to early Miocene, and seismic data are used to infer the transition from a shallow to normal depth prograding continental shelf with submarine canyons on the slope and channel/levees on the rise. Cores from the continental rise at Site 1165 show long-term (millions of years) early Miocene and younger decreases in sedimentation rates as well as short-term (Milankovitch periods) cyclicity between principally biogenic and terrigenous sediment supply-resulting from the cyclic presence of onshore glaciers and changes in ocean circulation. Middle Miocene transitions include rapid decreases in sedimentation rates, increased ice-rafted debris, shifts in clays and other minerals, and regional erosion of the slope and rise. These transitions may reflect enhanced glacial erosion and reduced glacial meltwater from progressively colder ice. At this time, seismic data show that depocenters began to shift from the outer continental rise to the base of the continental slope coincident with the initial stages of the glacial erosion and overdeepening of the continental shelf. During the late Miocene to early Pliocene there was a transition to greater subglacial activity on the shelf and more pronounced cyclic facies variations on the continental rise. At this time, severe glacial morphologies initiated on the shelf with the erosion of Prydz Channel and other troughs by fast-moving ice and the deposition of overcompacted glacial diamictons by slow-moving ice on adjacent banks. The Prydz trough-mouth fan also began to form with alternating deposition of debris flows (ice at shelf edge) and muddy units (reduced ice) (Site 1167). The fan also records a transition during the late Pleistocene for times younger than 780 k.y. when short-term glacial variations continued but ice reached the shelf edge only a few times. Both short-term and long-term transitions characterize the Cenozoic evolution of the Prydz Bay region from the Cretaceous nonglacial to late Neogene full-glacial paleoenvironments. These transitions are known only from ODP cores, and further insights will require additional drilling.